Grouped product items

SKU

Size

Availability

Price

Qty

P136335-250mg

250mg

$35.90

P136335-1g

Available within 4-8 weeks(?)

$109.90

P136335-5g

Available within 4-8 weeks(?)

$361.90

Basic Description

Synonyms	HY-108457 \| NSC50554 \| NSC-50554 \| UNII-9FYU45OV9H \| DTXCID7027592 \| DZKIUEHLEXLYKM-UHFFFAOYSA- \| 4-06-00-04937 (Beilstein Handbook Reference) \| Tox21_300618 \| BRN 2047057 \| GTPL4114 \| SY113803 \| Phenanthren-9-ol \| SCHEMBL508755 \| BDBM50526033 \| CCRIS 184
Specifications & Purity	Moligand™, technical grade
Biochemical and Physiological Mechanisms	Selective TRPM4 blocker (IC 50 = 20 μM). Modulates smooth muscle contraction. Reduces LPS-induced cell death. Promotes angiogenesis. Shows cardioprotective and anti-ischemic effects in vivo.
Shipped In	Normal
Grade	Moligand™, technical grade
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of TRPM4
Note	Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

AI Insight

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504751916
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504751916
IUPAC Name	phenanthren-9-ol
INCHI	InChI=1S/C14H10O/c15-14-9-10-5-1-2-6-11(10)12-7-3-4-8-13(12)14/h1-9,15H
InChi Key	DZKIUEHLEXLYKM-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)O
Isomeric SMILES	C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)O
WGK Germany	3
RTECS	SF8288000
PubChem CID	10229
Molecular Weight	194.23

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number	Certificate Type	Date	Item
L2405186	Certificate of Analysis	Sep 06, 2024	P136335
D1903146	Certificate of Analysis	Dec 08, 2022	P136335
A2226113	Certificate of Analysis	Feb 08, 2022	P136335

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	SF8288000

Reviews

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Chun-Ying Xu, Yuan-Yuan Cui, Cheng-Xiong Yang. (2024) Fabrication of magnetic Fe3O4 doped β-cyclodextrin microporous organic network for the efficient extraction of endocrine disrupting chemicals from food takeaway boxes. JOURNAL OF CHROMATOGRAPHY A, 1715 (464625). [PMID:38171066] [10.1016/j.chroma.2023.464625]
2. Kai Hu, Tiantian Pang, Cheng Yang, Pengzhao Han, Lixin Li, Pan Wang, Zhenqiang Zhang, Wenjie Zhao, Shusheng Zhang. (2023) Simultaneous extraction of hydroxylated polycyclic aromatic hydrocarbons and catecholamines with magnetic boronic acid hypercrosslinked polymers. JOURNAL OF CHROMATOGRAPHY A, 1712 (464491). [PMID:37931428] [10.1016/j.chroma.2023.464491]
3. Zhengwen Wei, Yifan Du, Xiang-fei Lü, Wei Wang, Roberta Del Sole, Giuseppe Mele, Zhen-Yi Jiang. (2023) High-performance Fe3O4-terephthalaldehyde magnetic-nanocomposite for removal phenanthrene and 9-phenanthrol: A comprehensive experimental and theoretical analysis. SEPARATION AND PURIFICATION TECHNOLOGY, 306 (122610). [PMID:] [10.1016/j.seppur.2022.122610]
4. Zhengwen Wei, Xiang-fei Lü, Wei Wang, Giuseppe Mele, Zhen-Yi Jiang. (2023) Excellent removal performance of 4,4'-biphenyldicarboxaldehyde m-phenylenediamine Schiff base magnetic polymer towards phenanthrene and 9-phenanthrol: Experimental, modeling and DFT calculations studies. JOURNAL OF HAZARDOUS MATERIALS, 441 (129920). [PMID:36099739] [10.1016/j.jhazmat.2022.129920]
5. Zhengwen Wei, Xiang-fei Lü, Wei Wang, Giuseppe Mele, Zhen-Yi Jiang. (2022) Fe3O4-4,4′-biphenyldicarboxaldehyde superparamagnetic-nanomaterial for the high-efficiency removal of 9-phenanthrol: experimental combined with DFT investigations. Environmental Science-Nano, 9 (9): (3562-3580). [PMID:] [10.1039/D2EN00543C]
6. Sun Fei, Feng Chao, Wang Yang, Yang Xue, Zhao Hong. (2022) Preparation of fluorescent polystyrene microspheres by improving swelling performance based on molecular weight and surface carboxyl group content. QUIMICA NOVA, 45 (2): (145-151). [PMID:] [10.21577/0100-4042.20170808]
7. Xin-Qiao He, Yuan-Yuan Cui, Cheng-Xiong Yang. (2021) Thiol–Yne Click Postsynthesis of a Sulfonate Group-Enriched Magnetic Microporous Organic Network for Efficient Extraction of Benzimidazole Fungicides. ACS Applied Materials & Interfaces, 13 (33): (39905–39914). [PMID:34374514] [10.1021/acsami.1c11148]
8. Xin-Qiao He, Yuan-Yuan Cui, Xiao-Hui Lin, Cheng-Xiong Yang. (2021) Fabrication of polyethyleneimine modified magnetic microporous organic network nanosphere for efficient enrichment of non-steroidal anti-inflammatory drugs from wastewater samples prior to HPLC-UV analysis. TALANTA, 233 (122471). [PMID:34215105] [10.1016/j.talanta.2021.122471]
9. Fan Libing, Ma Qianli, Tian Jiao, Li Dan, Xi Xue, Dong Xiangting, Yu Wensheng, Wang Jinxian, Liu Guixia. (2019) Conjugate Electrospinning Construction of Microyarns with Synchronous Color-Tuned Photoluminescence and Tunable Electrical Conductivity. JOURNAL OF ELECTRONIC MATERIALS, 48 (3): (1511-1521). [PMID:] [10.1007/s11664-018-06914-9]
10. Cholho Choe, Ling Yang, Zhanao Lv, Wanling Mo, Zhuqi Chen, Guangxin Li, Guochuan Yin,. (2015-04-24) Redox-inactive metal ions promoted the catalytic reactivity of non-heme manganese complexes towards oxygen atom transfer.. Dalton transactions (Cambridge, England : 2003), 44 ((19)): ( 9182-9192 ). [PMID:25904197]

References

1. Guinamard R, Hof T, Del Negro CA. (2014) The TRPM4 channel inhibitor 9-phenanthrol.. Br J Pharmacol, 171 (7): (1600-13). [PMID:24433510] [10.1021/op500134e]
2. Chun-Ying Xu, Yuan-Yuan Cui, Cheng-Xiong Yang. (2024) Fabrication of magnetic Fe3O4 doped β-cyclodextrin microporous organic network for the efficient extraction of endocrine disrupting chemicals from food takeaway boxes. JOURNAL OF CHROMATOGRAPHY A, 1715 (464625). [PMID:38171066] [10.1016/j.chroma.2023.464625]
3. Kai Hu, Tiantian Pang, Cheng Yang, Pengzhao Han, Lixin Li, Pan Wang, Zhenqiang Zhang, Wenjie Zhao, Shusheng Zhang. (2023) Simultaneous extraction of hydroxylated polycyclic aromatic hydrocarbons and catecholamines with magnetic boronic acid hypercrosslinked polymers. JOURNAL OF CHROMATOGRAPHY A, 1712 (464491). [PMID:37931428] [10.1016/j.chroma.2023.464491]
4. Zhengwen Wei, Yifan Du, Xiang-fei Lü, Wei Wang, Roberta Del Sole, Giuseppe Mele, Zhen-Yi Jiang. (2023) High-performance Fe3O4-terephthalaldehyde magnetic-nanocomposite for removal phenanthrene and 9-phenanthrol: A comprehensive experimental and theoretical analysis. SEPARATION AND PURIFICATION TECHNOLOGY, 306 (122610). [PMID:] [10.1016/j.seppur.2022.122610]
5. Zhengwen Wei, Xiang-fei Lü, Wei Wang, Giuseppe Mele, Zhen-Yi Jiang. (2023) Excellent removal performance of 4,4'-biphenyldicarboxaldehyde m-phenylenediamine Schiff base magnetic polymer towards phenanthrene and 9-phenanthrol: Experimental, modeling and DFT calculations studies. JOURNAL OF HAZARDOUS MATERIALS, 441 (129920). [PMID:36099739] [10.1016/j.jhazmat.2022.129920]
6. Zhengwen Wei, Xiang-fei Lü, Wei Wang, Giuseppe Mele, Zhen-Yi Jiang. (2022) Fe3O4-4,4′-biphenyldicarboxaldehyde superparamagnetic-nanomaterial for the high-efficiency removal of 9-phenanthrol: experimental combined with DFT investigations. Environmental Science-Nano, 9 (9): (3562-3580). [PMID:] [10.1039/D2EN00543C]
7. Sun Fei, Feng Chao, Wang Yang, Yang Xue, Zhao Hong. (2022) Preparation of fluorescent polystyrene microspheres by improving swelling performance based on molecular weight and surface carboxyl group content. QUIMICA NOVA, 45 (2): (145-151). [PMID:] [10.21577/0100-4042.20170808]
8. Xin-Qiao He, Yuan-Yuan Cui, Cheng-Xiong Yang. (2021) Thiol–Yne Click Postsynthesis of a Sulfonate Group-Enriched Magnetic Microporous Organic Network for Efficient Extraction of Benzimidazole Fungicides. ACS Applied Materials & Interfaces, 13 (33): (39905–39914). [PMID:34374514] [10.1021/acsami.1c11148]
9. Xin-Qiao He, Yuan-Yuan Cui, Xiao-Hui Lin, Cheng-Xiong Yang. (2021) Fabrication of polyethyleneimine modified magnetic microporous organic network nanosphere for efficient enrichment of non-steroidal anti-inflammatory drugs from wastewater samples prior to HPLC-UV analysis. TALANTA, 233 (122471). [PMID:34215105] [10.1016/j.talanta.2021.122471]
10. Fan Libing, Ma Qianli, Tian Jiao, Li Dan, Xi Xue, Dong Xiangting, Yu Wensheng, Wang Jinxian, Liu Guixia. (2019) Conjugate Electrospinning Construction of Microyarns with Synchronous Color-Tuned Photoluminescence and Tunable Electrical Conductivity. JOURNAL OF ELECTRONIC MATERIALS, 48 (3): (1511-1521). [PMID:] [10.1007/s11664-018-06914-9]
11. Cholho Choe, Ling Yang, Zhanao Lv, Wanling Mo, Zhuqi Chen, Guangxin Li, Guochuan Yin,. (2015-04-24) Redox-inactive metal ions promoted the catalytic reactivity of non-heme manganese complexes towards oxygen atom transfer.. Dalton transactions (Cambridge, England : 2003), 44 ((19)): ( 9182-9192 ). [PMID:25904197]

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9-Phenanthrol - Technical Grade, high purity , CAS No.484-17-3, Channel blocker of TRPM4