8-(4-Chlorophenylthio)guanosine 3′,5′-cyclic Monophosphate sodium salt - ≥95%(HPLC), high purity , CAS No.51239-26-0

Item Number

C336169

• Synonyms: sodium 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate | 8-(4-chlorophenylthio)-3',5'-cyclic GMP.Na | 8-pCPT-cGMP.Na | sodium (4aR,6R,7R,7aS)-6-{2-amino-8-[(4-chlorophenyl)sulfanyl]-6-oxo-1,6-dihydro-9H-purin-9-yl}-7-hydroxy-2-oxotetrahydro-2H,
• Specifications & Purity: ≥95%(HPLC)
• Biochemical and Physiological Mechanisms: Membrane permeable analog of cGMP that does not affect cGMP-regulated phosphodiesterase. A more potent cGMP analog than 8-Br-cGMP due to its higher membrane permeability and higher resistance to phosphodiesterase hydrolysis. Acts as a selective activator
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads

Product Description

8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate sodium salt (8-CPT-2'-O-Me-cAMP? Na ) is a selective activator of cGKI α, cGKI β, and cGKII (cGMP-dependent protein kinase (PKG) Iα, Iβ, and type II )as well as of CNG (cGMP-gated ion channels). The compounds higher activation potential as compared to cGMP, and retains excellent cell membrane permeability and phosphodiesterase stability. 8-CPT-2'-O-Me-cAMP ? Na has been preferred alternative to unsuitable analogs such as dibutyryl-cGMP.