Determine the necessary mass, volume, or concentration for preparing a solution.
Basic Description
| Synonyms | 6-Chloro-2,4-dihydroxypyrimidine | 4-Chlorouracil | SB55682 | 4-Chloro-2,6-dihydroxypyrimidine | F1923-0053 | C2093 | PKUFNWPSFCOSLU-UHFFFAOYSA- | 2,4-Pyrimidinediol, 6-chloro- (9CI) | A18768 | G9BH09J4JW | 6-Chloro-2,4(1H,3H)-pyrimidinedione # | InChI=1/ |
|---|---|
| Specifications & Purity | ≥99% |
| Shipped In | Normal |
| Product Description | Product Describtion: the effects of halogenation on nucleic acid base-pair stability and alkali metal ion affinity. Reaction of 6-chlorouracil with 4-(dimethylamino)pyridine, 4-methylpyridine, and pyridin-4-yl-morpholine yielded pyridinium-substituted uracils as chlorides which were converted into pyridinium uracilates by deprotonation. These heterocyclic mesomeric betaines are cross-conjugated and thus possess separate cationic (pyridinium) and anionic (uracilate) moieties. Calculations and X-ray single crystal analyses may be used to characterize these systems and to compare the salts with the betaines Product Application: Chlorouracil (4-Chlorouracil; 6-Chlorouracil) is a halogenated uracil that is useful in studies of the effects of halogenation on nucleic acid base-pair stability and alkali metal ion affinity. Reaction of 6-chlorouracil with 4-(dimethylamino)pyridine, 4-methylpyridine, and pyridin-4-yl-morpholine yielded pyridinium-substituted uracils as chlorides which were converted into pyridinium uracilates by deprotonation. These heterocyclic mesomeric betaines are cross-conjugated and thus possess separate cationic (pyridinium) and anionic (uracilate) moieties. Calculations and X-ray single crystal analyses may be used to characterize these systems and to compare the salts with the betaines. |
AI Insight
Names and Identifiers
| Pubchem Sid | 488184773 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488184773 |
| IUPAC Name | 6-chloro-1H-pyrimidine-2,4-dione |
| INCHI | InChI=1S/C4H3ClN2O2/c5-2-1-3(8)7-4(9)6-2/h1H,(H2,6,7,8,9) |
| InChi Key | PKUFNWPSFCOSLU-UHFFFAOYSA-N |
| Canonical SMILES | C1=C(NC(=O)NC1=O)Cl |
| Isomeric SMILES | C1=C(NC(=O)NC1=O)Cl |
| WGK Germany | 3 |
| PubChem CID | 73272 |
| Molecular Weight | 146.53 |
| Beilstein | 120492 |
| Reaxy-Rn | 120492 |
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 G2429239 | Certificate of Analysis | Jun 25, 2024 | C122459 |
| G2429240 | Certificate of Analysis | Jun 25, 2024 | C122459 |
| G2429241 | Certificate of Analysis | Jun 25, 2024 | C122459 |
| C2304357 | Certificate of Analysis | Dec 20, 2022 | C122459 |
| C2304360 | Certificate of Analysis | Dec 20, 2022 | C122459 |
| C2304361 | Certificate of Analysis | Dec 20, 2022 | C122459 |
| C2304365 | Certificate of Analysis | Dec 20, 2022 | C122459 |
| C2304367 | Certificate of Analysis | Dec 20, 2022 | C122459 |
| C2304368 | Certificate of Analysis | Dec 20, 2022 | C122459 |
| H1412266 | Certificate of Analysis | Jun 14, 2022 | C122459 |
| H1412265 | Certificate of Analysis | Jun 14, 2022 | C122459 |
| H1412264 | Certificate of Analysis | Jun 14, 2022 | C122459 |
| B1419058 | Certificate of Analysis | Mar 15, 2022 | C122459 |
| C1823112 | Certificate of Analysis | Jan 21, 2022 | C122459 |
| C1823113 | Certificate of Analysis | Jan 21, 2022 | C122459 |
Show more⌵
Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| Reaxy-Rn | 120492 |
Related Documents
Reviews
Customer Reviews
Citations of This Product
| 1. Chao Fan, Bei Liu, Hui Li, Kaijun Quan, Jia Chen, Hongdeng Qiu. (2021) N-Vinyl pyrrolidone and undecylenic acid copolymerized on silica surface as mixed-mode stationary phases for reversed-phase and hydrophilic interaction chromatography. JOURNAL OF CHROMATOGRAPHY A, 1655 (462534). [PMID:34509123] [10.1016/j.chroma.2021.462534] |
| 2. Chao Fan, Hao Tang, Licheng Wang, Yijing Li, Xusheng Wang, Shuai Wang, Xiaojing Liang. (2020) The preparation of a core–shell stationary phase by the in situ polymerization of a hydrophilic polymer on the surface of silica and its chromatographic performance. NEW JOURNAL OF CHEMISTRY, 44 (27): (11704-11709). [PMID:] [10.1039/D0NJ01197E] |
| 3. Tiantian Si, Xiao Song, Licheng Wang, Yong Guo, Xiaojing Liang, Shuai Wang. (2020) Preparation and evaluation of hydrophobically associating polyacrylamide coated silica composite as high performance liquid chromatographic stationary phase. MICROCHEMICAL JOURNAL, 152 (104330). [PMID:] [10.1016/j.microc.2019.104330] |
| 4. Yuhuan Wang,Ruyan Wang,Lei Wang,Licheng Wang,Yong Guo,Xiaojing Liang,Shuai Wang. (2019-03-28) Nanogold hybrid silica gel and its 1-octadecanethiol self-assembled modified composite as a stationary phase for liquid chromatography.. The Analyst, 144 ((9)): (3072-3079). [PMID:30916685] |
References
| 1. Chao Fan, Bei Liu, Hui Li, Kaijun Quan, Jia Chen, Hongdeng Qiu. (2021) N-Vinyl pyrrolidone and undecylenic acid copolymerized on silica surface as mixed-mode stationary phases for reversed-phase and hydrophilic interaction chromatography. JOURNAL OF CHROMATOGRAPHY A, 1655 (462534). [PMID:34509123] [10.1016/j.chroma.2021.462534] |
| 2. Chao Fan, Hao Tang, Licheng Wang, Yijing Li, Xusheng Wang, Shuai Wang, Xiaojing Liang. (2020) The preparation of a core–shell stationary phase by the in situ polymerization of a hydrophilic polymer on the surface of silica and its chromatographic performance. NEW JOURNAL OF CHEMISTRY, 44 (27): (11704-11709). [PMID:] [10.1039/D0NJ01197E] |
| 3. Tiantian Si, Xiao Song, Licheng Wang, Yong Guo, Xiaojing Liang, Shuai Wang. (2020) Preparation and evaluation of hydrophobically associating polyacrylamide coated silica composite as high performance liquid chromatographic stationary phase. MICROCHEMICAL JOURNAL, 152 (104330). [PMID:] [10.1016/j.microc.2019.104330] |
| 4. Yuhuan Wang,Ruyan Wang,Lei Wang,Licheng Wang,Yong Guo,Xiaojing Liang,Shuai Wang. (2019-03-28) Nanogold hybrid silica gel and its 1-octadecanethiol self-assembled modified composite as a stationary phase for liquid chromatography.. The Analyst, 144 ((9)): (3072-3079). [PMID:30916685] |