5-Iodotubercidin - ≥98%, high purity , CAS No.24386-93-4

  • ≥98%
Item Number
L125077
Grouped product items
SKUSizeAvailabilityPrice Qty
L125077-5mg
5mg
2
$112.90
L125077-25mg
25mg
1
$439.90
L125077-250mg
250mg
2
$3,960.90
L125077-1g
1g
2
$14,256.90

Potent, adenosine kinase inhibitor

Basic Description

Synonyms(2R,3R,4S,5R)-2-(4-amino-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol | A848734 | BDBM50375654 | NSC 113939, 5-ITu | 2-(4-Amino-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol | 5-Iodotubericidin, >=
Specifications & Purity≥98%
Biochemical and Physiological Mechanisms5-Iodotubercidin (Itu) has been shown to inhibit mitogen-activated protein kinase (ERK2) (Ki = 525 nM), adenosine kinase (ADK) (Ki = 30 nM), casein kinases 1 & 2 (CSNK1A1 & CSNK2A1), protein kinase A (PKA) and insulin receptor kinase (IC50 ranging from 0.
Storage TempProtected from light,Store at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

5-Iodotubercidin(NSC 113939; 5-ITu) is a potent adenosine kinase inhibitor (IC50 = 26 nM).
A potent and competitive inhibitor of ERK2, PKA, and ADK.

AI Insight

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid504756361
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504756361
IUPAC Name (2R,3R,4S,5R)-2-(4-amino-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
INCHI InChI=1S/C11H13IN4O4/c12-4-1-16(10-6(4)9(13)14-3-15-10)11-8(19)7(18)5(2-17)20-11/h1,3,5,7-8,11,17-19H,2H2,(H2,13,14,15)/t5-,7-,8-,11-/m1/s1
InChi Key WHSIXKUPQCKWBY-IOSLPCCCSA-N
Canonical SMILES C1=C(C2=C(N=CN=C2N1C3C(C(C(O3)CO)O)O)N)I
Isomeric SMILES C1=C(C2=C(N=CN=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N)I
PubChem CID 97297
Molecular Weight 392.15

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot NumberCertificate TypeDateItem
C23211019Certificate of AnalysisJan 09, 2025 L125077
F22041002Certificate of AnalysisMar 14, 2024 L125077
F22041003Certificate of AnalysisMar 14, 2024 L125077
F2204889Certificate of AnalysisMar 14, 2024 L125077
J1520092Certificate of AnalysisMay 10, 2023 L125077

Related Documents

Reviews

Customer Reviews

Citations of This Product

1. Zeng Sen, Hou Yaqi, Zhou Yaming, Zhou Xi, Ye Shefang, Wang Miao, Ren Lei.  (2022)  Adsorptive removal of uremic toxins using Zr-based MOFs for potential hemodialysis membranes.  JOURNAL OF MATERIALS SCIENCE,  57  (4): (2909-2923).  [PMID:] [10.1007/s10853-021-06783-4]
2. Peiling Wang, Xiangmei Hua, Yang Sun, Hongyu Li, Yuge Han Bryner, Richard P. Hsung, Jun Dai.  (2021)  Loss of haspin suppresses cancer cell proliferation by interfering with cell cycle progression at multiple stages.  FASEB JOURNAL,  35  (10): (e21923).  [PMID:34551143] [10.1096/fj.202100099R]

References

1. Huang L et al..  (2014)  Enhanced expression of WD repeat-containing protein 35 via CaMKK/AMPK activation in bupivacaine-treated Neuro2a cells..  PLoS One,  (5): (e98185).  [PMID:24859235]
2. Zeng Sen, Hou Yaqi, Zhou Yaming, Zhou Xi, Ye Shefang, Wang Miao, Ren Lei.  (2022)  Adsorptive removal of uremic toxins using Zr-based MOFs for potential hemodialysis membranes.  JOURNAL OF MATERIALS SCIENCE,  57  (4): (2909-2923).  [PMID:] [10.1007/s10853-021-06783-4]
3. Peiling Wang, Xiangmei Hua, Yang Sun, Hongyu Li, Yuge Han Bryner, Richard P. Hsung, Jun Dai.  (2021)  Loss of haspin suppresses cancer cell proliferation by interfering with cell cycle progression at multiple stages.  FASEB JOURNAL,  35  (10): (e21923).  [PMID:34551143] [10.1096/fj.202100099R]

Solution Calculators