5-Iodotubercidin (Itu) has been shown to inhibit mitogen-activated protein kinase (ERK2) (Ki = 525 nM), adenosine kinase (ADK) (Ki = 30 nM), casein kinases 1 & 2 (CSNK1A1 & CSNK2A1), protein kinase A (PKA) and insulin receptor kinase (IC50 ranging from 0.
Storage Temp
Protected from light,Store at -20°C
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
5-Iodotubercidin(NSC 113939; 5-ITu) is a potent adenosine kinase inhibitor (IC50 = 26 nM). A potent and competitive inhibitor of ERK2, PKA, and ADK.
1.Zeng Sen, Hou Yaqi, Zhou Yaming, Zhou Xi, Ye Shefang, Wang Miao, Ren Lei. (2022) Adsorptive removal of uremic toxins using Zr-based MOFs for potential hemodialysis membranes. JOURNAL OF MATERIALS SCIENCE, 57 (4):(2909-2923). [PMID:][10.1007/s10853-021-06783-4]
2.Peiling Wang, Xiangmei Hua, Yang Sun, Hongyu Li, Yuge Han Bryner, Richard P. Hsung, Jun Dai. (2021) Loss of haspin suppresses cancer cell proliferation by interfering with cell cycle progression at multiple stages. FASEB JOURNAL, 35 (10):(e21923). [PMID:34551143][10.1096/fj.202100099R]
References
1.Huang L et al.. (2014) Enhanced expression of WD repeat-containing protein 35 via CaMKK/AMPK activation in bupivacaine-treated Neuro2a cells.. PLoS One, 9 (5):(e98185). [PMID:24859235]
2.Zeng Sen, Hou Yaqi, Zhou Yaming, Zhou Xi, Ye Shefang, Wang Miao, Ren Lei. (2022) Adsorptive removal of uremic toxins using Zr-based MOFs for potential hemodialysis membranes. JOURNAL OF MATERIALS SCIENCE, 57 (4):(2909-2923). [PMID:][10.1007/s10853-021-06783-4]
3.Peiling Wang, Xiangmei Hua, Yang Sun, Hongyu Li, Yuge Han Bryner, Richard P. Hsung, Jun Dai. (2021) Loss of haspin suppresses cancer cell proliferation by interfering with cell cycle progression at multiple stages. FASEB JOURNAL, 35 (10):(e21923). [PMID:34551143][10.1096/fj.202100099R]
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