| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| E276476-10mg | 10mg | 5 | $14.90 | |
| E276476-100mg | 100mg | 2 | $114.90 | |
| E276476-250mg | 250mg | 2 | $229.90 | |
| E276476-1g | 1g | 2 | $739.90 |
Uridine analog. Click chemistry RNA transcription label.
| Synonyms | 5-EU | AKOS024462949 | 5-ethynyl uridine | DS-8002 | EX-A3665 | GLXC-25273 | AC-32359 | QCWBIPKYTBFWHH-FDDDBJFASA-N | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-ethynylpyrimidine-2,4-dione | 5-Ethynyl Uridine (EU) | C76184 | Uridine, 5 |
|---|---|
| Specifications & Purity | ≥99% |
| Biochemical and Physiological Mechanisms | Uridine analog. Click chemistry RNA transcription label. Incorporates into RNA during active RNA synthesis. Does not incorporate into DNA. Reacts with azide-containing detection reagents. |
| Storage Temp | Protected from light,Store at -20°C,Argon charged,Desiccated |
| Shipped In | Ice chest + Ice pads |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description | Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. |
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Pubchem Sid | 488198755 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488198755 |
| IUPAC Name | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-ethynylpyrimidine-2,4-dione |
| INCHI | InChI=1S/C11H12N2O6/c1-2-5-3-13(11(18)12-9(5)17)10-8(16)7(15)6(4-14)19-10/h1,3,6-8,10,14-16H,4H2,(H,12,17,18)/t6-,7-,8-,10-/m1/s1 |
| InChi Key | QCWBIPKYTBFWHH-FDDDBJFASA-N |
| Canonical SMILES | C#CC1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O |
| Isomeric SMILES | C#CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O |
| PubChem CID | 14885960 |
| Molecular Weight | 268.22 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 B2301684 | Certificate of Analysis | Feb 01, 2024 | E276476 |
| B2301672 | Certificate of Analysis | Nov 08, 2023 | E276476 |
| B2301852 | Certificate of Analysis | Nov 08, 2023 | E276476 |
| B2301858 | Certificate of Analysis | Nov 08, 2023 | E276476 |
| B2301881 | Certificate of Analysis | Nov 08, 2023 | E276476 |
| 1. Perea-Resa C et al.. (2020) Cohesin Removal Reprograms Gene Expression upon Mitotic Entry.. Mol Cell, 78 (127-140.e7). [PMID:32035037] |
| 2. Prusty AB et al.. (2017) Impaired spliceosomal UsnRNP assembly leads to Sm mRNA down-regulation and Sm protein degradation.. J Cell Biol, 216 (8): (2391-2407). [PMID:28637748] |
| 3. Pavlova NN et al.. (2020) Translation in amino-acid-poor environments is limited by tRNAGln charging.. Elife, 9 [PMID:33289483] |
