Basic Description

Synonyms	30827-99-7 \| 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride \| AEBSF HCl \| AEBSF \| AEBSF hydrochloride \| Pefabloc SC \| Pefabloc \| 4-(2-Aminoethyl)benzene-1-sulfonyl fluoride hydrochloride \| AEBSF (hydrochloride) \| 4-(2-Aminoethyl)benzenesulphonyl fluoride hydrochlor
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, impr
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Recommended concentrations for use are .1-1 mM.

AI Insight

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4-(2-aminoethyl)benzenesulfonyl fluoride;hydrochloride
INCHI	InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChi Key	WRDABNWSWOHGMS-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl
Isomeric SMILES	C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl
WGK Germany	3
PubChem CID	186136
UN Number	3261
Molecular Weight	239.69
Beilstein	7604627
Reaxy-Rn	7604627

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Safety and Hazards(GHS)

Pictogram(s)	GHS05
Signal	Danger
Hazard Statements	H314:Causes severe skin burns and eye damage
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician.
WGK Germany	3
Reaxy-Rn	7604627

FAQs and Articles

FAQ

SuFEx: Sulfonyl Fluorides that Participate in the Next Click Reaction

Categories: Technical articles

Reviews

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Chenglin Li, Sifan Li, Xinsheng Li, Tao Yuan, Jialei Xu, Xixin Gu, Jianli Hua. (2023) A Turn-On Lipid Droplet-Targeted Near-Infrared Fluorescent Probe with a Large Stokes Shift for Detection of Intracellular Carboxylesterases and Cell Viability Imaging. MOLECULES, 28 (5): (2317). [PMID:36903562] [10.3390/molecules28052317]
2. Yi-Xuan Fu, Wu-Yingzheng Guo, Nan Wang, Yi-Jie Dai, Zi-Ye Zhang, Xin-Lin Sun, Wen-Chao Yang, Guang-Fu Yang. (2022) Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor. ANALYTICAL CHEMISTRY, 94 (50): (17692–17699). [PMID:36469707] [10.1021/acs.analchem.2c04614]
3. Jingmin Zhang, Youmei Peng, Ying Li, Ning Wang, Yuna Chai, Chongzhen Qin, Xinru Wang, Suna Liu, Yubing Zhou, Xiaojian Zhang, Wenda Zhang. (2022) Development of a near-infrared fluorescent probe with large Stokes shift for carboxylesterases detection and its application in living systems. DYES AND PIGMENTS, 198 (109993). [PMID:] [10.1016/j.dyepig.2021.109993]
4. Yu Zhu Yang, Zi Yi Xu, Nian Bing Li, Hong Qun Luo. (2021) Ultrasensitive fluorescent probe for visual biosensing of esterase activity in living cells and its imaging application. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 262 (120094). [PMID:34175764] [10.1016/j.saa.2021.120094]
5. Shuli Man, Miao Li, Jin Zhou, Haiyue Wang, Jinyan Zhang, Long Ma. (2019) Polyethyleneimine coated Fe3O4 magnetic nanoparticles induce autophagy, NF-κB and TGF-β signaling pathway activation in HeLa cervical carcinoma cells via reactive oxygen species generation. Biomaterials Science, 8 (1): (201-211). [PMID:31664285] [10.1039/C9BM01563A]
6. Hui Zhou, Jinbao Tang, Jie Zhang, Bochao Chen, Jianfei Kan, Weifen Zhang, Jin Zhou, Huimin Ma. (2019) A red lysosome-targeted fluorescent probe for carboxylesterase detection and bioimaging. Journal of Materials Chemistry B, 7 (18): (2989-2996). [PMID:] [10.1039/C9TB00310J]
7. Juan Wang, Mengmeng Song, Chengguo Hu, Kangbing Wu. (2018) Portable, Self-Powered, and Light-Addressable Photoelectrochemical Sensing Platforms Using pH Meter Readouts for High-Throughput Screening of Thrombin Inhibitor Drugs. ANALYTICAL CHEMISTRY, 90 (15): (9366–9373). [PMID:29998727] [10.1021/acs.analchem.8b01979]

References

1. Chenglin Li, Sifan Li, Xinsheng Li, Tao Yuan, Jialei Xu, Xixin Gu, Jianli Hua. (2023) A Turn-On Lipid Droplet-Targeted Near-Infrared Fluorescent Probe with a Large Stokes Shift for Detection of Intracellular Carboxylesterases and Cell Viability Imaging. MOLECULES, 28 (5): (2317). [PMID:36903562] [10.3390/molecules28052317]
2. Yi-Xuan Fu, Wu-Yingzheng Guo, Nan Wang, Yi-Jie Dai, Zi-Ye Zhang, Xin-Lin Sun, Wen-Chao Yang, Guang-Fu Yang. (2022) Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor. ANALYTICAL CHEMISTRY, 94 (50): (17692–17699). [PMID:36469707] [10.1021/acs.analchem.2c04614]
3. Jingmin Zhang, Youmei Peng, Ying Li, Ning Wang, Yuna Chai, Chongzhen Qin, Xinru Wang, Suna Liu, Yubing Zhou, Xiaojian Zhang, Wenda Zhang. (2022) Development of a near-infrared fluorescent probe with large Stokes shift for carboxylesterases detection and its application in living systems. DYES AND PIGMENTS, 198 (109993). [PMID:] [10.1016/j.dyepig.2021.109993]
4. Yu Zhu Yang, Zi Yi Xu, Nian Bing Li, Hong Qun Luo. (2021) Ultrasensitive fluorescent probe for visual biosensing of esterase activity in living cells and its imaging application. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 262 (120094). [PMID:34175764] [10.1016/j.saa.2021.120094]
5. Shuli Man, Miao Li, Jin Zhou, Haiyue Wang, Jinyan Zhang, Long Ma. (2019) Polyethyleneimine coated Fe3O4 magnetic nanoparticles induce autophagy, NF-κB and TGF-β signaling pathway activation in HeLa cervical carcinoma cells via reactive oxygen species generation. Biomaterials Science, 8 (1): (201-211). [PMID:31664285] [10.1039/C9BM01563A]
6. Hui Zhou, Jinbao Tang, Jie Zhang, Bochao Chen, Jianfei Kan, Weifen Zhang, Jin Zhou, Huimin Ma. (2019) A red lysosome-targeted fluorescent probe for carboxylesterase detection and bioimaging. Journal of Materials Chemistry B, 7 (18): (2989-2996). [PMID:] [10.1039/C9TB00310J]
7. Juan Wang, Mengmeng Song, Chengguo Hu, Kangbing Wu. (2018) Portable, Self-Powered, and Light-Addressable Photoelectrochemical Sensing Platforms Using pH Meter Readouts for High-Throughput Screening of Thrombin Inhibitor Drugs. ANALYTICAL CHEMISTRY, 90 (15): (9366–9373). [PMID:29998727] [10.1021/acs.analchem.8b01979]

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4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride - 10mM in DMSO, high purity , CAS No.30827-99-7