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3-(Methylsulfonyl)propanenitrile - ≥98%, high purity , NACHT, LRR and PYD domains-containing protein 3 inhibitor, CAS No.54863-37-5, NACHT, LRR and PYD domains-containing protein 3 inhibitor

Moligand™

≥98%

CAS#: 54863-37-5
Molecular Weight: 133.17
PubChem CID: 12714644
PubChem SID: 488198226

Item Number

D286906

Grouped product items
SKU	Size	Availability	Price
D286906-10mg	10mg	6	$78.90
D286906-50mg	50mg	5	$276.90
D286906-250mg	250mg	5	$1,246.90
D286906-1g	1g	3	$4,487.90

NLRP3 inflammasome inhibitor; disrupts inflammasome formation

View related series

Immunology/Inflammation (0) NLRP3 Inhibitor (0) NOD-like Receptor (NLR) (0)

Basic Description

Synonyms	A936206 \| 3-methanesulfonylpropanenitrile \| HY-17629 \| Tox21_301069 \| AKOS010140086 \| 3-(methanesulfonyl)propanenitrile \| Dapansutrile (USAN/INN) \| BDBM50505850 \| 3-(methylsulfonyl)propanenitrile \| Dapansutrile [INN] \| s8907 \| 3-methylsulphonyl-propionitr
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	NLRP3 inflammasome inhibitor that disrupts inflammasome formation. Reduces LPS/ATP-induced IL-1β secretion in human and mouse macrophagesin vitro, without affecting TNFα levels. Reduces LPS-induced inflammationin vivo. Also reduces joint swelling and mark
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	NACHT, LRR and PYD domains-containing protein 3 inhibitor

Names and Identifiers

Pubchem Sid	488198226
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488198226
IUPAC Name	3-methylsulfonylpropanenitrile
INCHI	InChI=1S/C4H7NO2S/c1-8(6,7)4-2-3-5/h2,4H2,1H3
InChi Key	LQFRYKBDZNPJSW-UHFFFAOYSA-N
Canonical SMILES	CS(=O)(=O)CCC#N
Isomeric SMILES	CS(=O)(=O)CCC#N
PubChem CID	12714644
Molecular Weight	133.17

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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8 results found

Lot Number	Certificate Type	Date	Item
D2326244	Certificate of Analysis	Mar 29, 2023	D286906
D2326252	Certificate of Analysis	Mar 29, 2023	D286906
D2326256	Certificate of Analysis	Mar 29, 2023	D286906
D2326257	Certificate of Analysis	Mar 29, 2023	D286906
D2326287	Certificate of Analysis	Mar 29, 2023	D286906
D2326507	Certificate of Analysis	Mar 29, 2023	D286906
D2326513	Certificate of Analysis	Mar 29, 2023	D286906
D2326518	Certificate of Analysis	Mar 29, 2023	D286906

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

References

1. Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A et al.. (2018) OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.. Proc Natl Acad Sci USA, 115 (7): (E1530-E1539). [PMID:29378952] [10.1021/op500134e]
2. Zhou W, Chen C, Chen Z, Liu L, Jiang J, Wu Z, Zhao M, Chen Y. (2018) NLRP3: A Novel Mediator in Cardiovascular Disease.. J Immunol Res, 2018 (13): (5702103). [PMID:29850631] [10.1021/op500134e]
3. Marchetti C, Swartzwelter B, Koenders MI, Azam T, Tengesdal IW, Powers N, de Graaf DM, Dinarello CA, Joosten LAB. (2018) NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis.. Arthritis Res Ther, 20 (1): (169). [PMID:30075804] [10.1021/op500134e]

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3-(Methylsulfonyl)propanenitrile - ≥98%, high purity , NACHT, LRR and PYD domains-containing protein 3 inhibitor, CAS No.54863-37-5, NACHT, LRR and PYD domains-containing protein 3 inhibitor

Basic Description

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Product Properties

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Safety and Hazards(GHS)

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Solution Calculators

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