Grouped product items

SKU

Size

Availability

Price

Qty

I133400-1g

Available within 8-12 weeks(?)

$9.90

I133400-5g

Available within 1-2 weeks(?)

$19.90

I133400-25g

25g

Available within 1-2 weeks(?)

$76.90

I133400-100g

100g

$273.90

I133400-500g

500g

Available within 4-8 weeks(?)

$1,231.90

Basic Description

Synonyms	2,5-Cyclohexadiene-1,4-dione, 2-(1,1-dimethylethyl)- \| 2-tert-Butyl-1,4-benzoquinone, 98% \| 2-tert-Butyl-p-benzoquinone \| t-butylbenzoquinone \| 2,5-Cyclohexadien-1,4-dione, 2-(1,1-dimethylethyl)- \| 2-tert-Butyl-[1,4]benzoquinone \| 2-tert-Butylbenzo-1,4-qu
Specifications & Purity	≥98%(GC)
Shipped In	Normal

AI Insight

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488182533
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488182533
IUPAC Name	2-tert-butylcyclohexa-2,5-diene-1,4-dione
INCHI	InChI=1S/C10H12O2/c1-10(2,3)8-6-7(11)4-5-9(8)12/h4-6H,1-3H3
InChi Key	NCCTVAJNFXYWTM-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)C1=CC(=O)C=CC1=O
Isomeric SMILES	CC(C)(C)C1=CC(=O)C=CC1=O
WGK Germany	3
RTECS	DK3790000
PubChem CID	19211
Molecular Weight	164.2
Beilstein	7(4)2100
Reaxy-Rn	1860944

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot Number	Certificate Type	Date	Item
J1527018	Certificate of Analysis	May 11, 2023	I133400
L2219060	Certificate of Analysis	Jan 06, 2023	I133400
C1506049	Certificate of Analysis	Oct 14, 2022	I133400
I2206712	Certificate of Analysis	Jul 23, 2022	I133400
I2206713	Certificate of Analysis	Jul 23, 2022	I133400
I2206717	Certificate of Analysis	Jul 23, 2022	I133400
I2206888	Certificate of Analysis	Jul 23, 2022	I133400
G2014094	Certificate of Analysis	May 10, 2022	I133400
G2014093	Certificate of Analysis	May 10, 2022	I133400

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS09, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H331:Toxic if inhaled H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	DK3790000
Reaxy-Rn	1860944

Reviews

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Xianghe Meng,Chaosheng Xia,Qin Ye,Xiaohua Nie. (2020-05-01) tert-Butyl-p-benzoquinone induces autophagy by inhibiting the Akt/mTOR signaling pathway in RAW 264.7 cells.. Food & function, 11 ((5)): (4193-4201). [PMID:32352125]
2. Yu Miao,Yanling Wu,Yingjin Jin,Mengze Lei,Jixing Nan,Xue Wu. (2020-01-15) Benzoquinone derivatives with antioxidant activity inhibit activated hepatic stellate cells and attenuate liver fibrosis in TAA-induced mice.. Chemico-biological interactions, 317 (108945-108945). [PMID:31935363]
3. Ningxiang Yu, Zeyi Wu, Yijue Wang, Abel Wend-Soo Zongo, Xiaohua Nie, Yuanchao Lu, Qin Ye, Xianghe Meng. (2024) Formation of adducts during digestion triggered dietary protein for alleviating cytotoxicity of 2-tert-butyl-1,4-benzoquinone. FOOD AND CHEMICAL TOXICOLOGY, 183 (25): (114200). [PMID:38029872] [10.1016/j.fct.2023.114200]

References

1. S W Cummings,B B Curtis,J A Peterson,R A Prough. (1990-09-01) The effect of the tert-butylquinone metabolite of butylated hydroxyanisole on cytochrome P-450 monooxygenase activity.. Xenobiotica; the fate of foreign compounds in biological systems, 20 ((9)): (915-924). [PMID:2122606]
2. K Morimoto,K Tsuji,T Iio,N Miyata,A Uchida,R Osawa,H Kitsutaka,A Takahashi. (1991-04-01) DNA damage in forestomach epithelium from male F344 rats following oral administration of tert-butylquinone, one of the forestomach metabolites of 3-BHA.. Carcinogenesis, 12 ((4)): (703-708). [PMID:2013134]
3. R M Vos,B Van Ommen,M S Hoekstein,J H De Goede,P J Van Bladeren. (1989-01-01) Irreversible inhibition of rat hepatic glutathione S-transferase isoenzymes by a series of structurally related quinones.. Chemico-biological interactions, 71 ((4)): (381-392). [PMID:2582541]
4. W H Kalus,R Münzner,W G Filby. (1994-01-01) The reaction of butylated hydroxyanisole and its metabolites with some arylamines: investigations of product mutagenicity.. Environmental health perspectives, 102 ((1)): (96-99). [PMID:9719675]
5. T Okubo,Y Yokoyama,K Kano,I Kano. (2003-03-28) Cell death induced by the phenolic antioxidant tert-butylhydroquinone and its metabolite tert-butylquinone in human monocytic leukemia U937 cells.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 41 ((5)): (679-688). [PMID:12659721]
6. Fa Zhang,Alan Chang,Ken Karaisz,Rong Feng,Jane Cai. (2004-03-17) Structural identification of extractables from rubber closures used for pre-filled semisolid drug applicator by chromatography, mass spectrometry, and organic synthesis.. Journal of pharmaceutical and biomedical analysis, 34 ((5)): (841-849). [PMID:15019018]
7. Malte Rolff,Julia Schottenheim,Gerhard Peters,Felix Tuczek. (2010-07-24) The first catalytic tyrosinase model system based on a mononuclear copper(I) complex: kinetics and mechanism.. Angewandte Chemie (International ed. in English), 49 ((36)): (6438-6442). [PMID:20652917]
8. Albert Braeuning,Silvia Vetter,Silvia Orsetti,Michael Schwarz. (2012-04-03) Paradoxical cytotoxicity of tert-butylhydroquinone in vitro: What kills the untreated cells?. Archives of toxicology, 86 ((9)): (1481-1487). [PMID:22466069]
9. Toshiyuki Matsunaga,Satoshi Endo,Mayuko Takemura,Midori Soda,Keiko Yamamura,Kazuo Tajima,Takeshi Miura,Tomoyuki Terada,Ossama El-Kabbani,Akira Hara. (2012-04-14) Reduction of cytotoxic p-quinone metabolites of tert-butylhydroquinone by human aldo-keto reductase (AKR) 1B10.. Drug metabolism and pharmacokinetics, 27 ((5)): (553-558). [PMID:22498646]
10. Svetlana N Samovich, Anastasia A Sladkova, Roman L Sverdlov, Irina P Edimecheva, Oleg I Shadyro,. (2019-04-22) Effects of quinones and nitroazoles on free-radical fragmentation of glycerol-1-phosphate and 1,2-dimyristoyl-glycero-3-phosphatidyl-glycerol.. Chemistry and physics of lipids, ( 8-14 ). [PMID:31005671]
11. Nan Shu,Lasse G Lorentzen,Michael J Davies. (2019-04-27) Reaction of quinones with proteins: Kinetics of adduct formation, effects on enzymatic activity and protein structure, and potential reversibility of modifications.. Free radical biology & medicine, 137 (169-180). [PMID:31026584]
12. Xianghe Meng,Chaosheng Xia,Qin Ye,Xiaohua Nie. (2020-05-01) tert-Butyl-p-benzoquinone induces autophagy by inhibiting the Akt/mTOR signaling pathway in RAW 264.7 cells.. Food & function, 11 ((5)): (4193-4201). [PMID:32352125]
13. B Bergmann,J K Dohrmann,R Kahl. (1992-09-01) Formation of the semiquinone anion radical from tert-butylquinone and from tert-butylhydroquinone in rat liver microsomes.. Toxicology, 74 ((2-3)): (127-133). [PMID:1325685]
14. A Sakai,N Miyata,A Takahashi. (1990-11-01) Initiating activity of 3-tert-butyl-4-hydroxyanisole (3-BHA) and its metabolites in two-stage transformation of BALB/3T3 cells.. Carcinogenesis, 11 ((11)): (1985-1988). [PMID:2225330]
15. W H Kalus,R Münzner,W G Filby. (1990-03-01) Isolation and characterization of some products of the BHA-nitrite reaction: examination of their mutagenicity.. Food additives and contaminants, 7 ((2)): (223-233). [PMID:2354741]
16. R Kahl,S Weinke,H Kappus. (1989-12-01) Production of reactive oxygen species due to metabolic activation of butylated hydroxyanisole.. Toxicology, 59 ((2)): (179-194). [PMID:2555935]
17. M Mizuno,A Ohara,G Danno,K Kanazawa,M Natake. (1987-02-01) Mutagens formed from butylated hydroxyanisole treated with nitrite under acidic conditions.. Mutation research, 176 ((2)): (179-184). [PMID:3100946]
18. C G Rogers,B G Boyes,T I Matula,G Neville,R Stapley. (1993-03-01) Cytotoxic and genotoxic properties of tert.-butyl-p-quinone (TBQ) in an in vitro assay system with Chinese hamster V79 cells and in strain D7 of Saccharomyces cerevisiae.. Mutation research, 299 ((1)): (9-18). [PMID:7679195]
19. P A Schilderman,E Rhijnsburger,I Zwingmann,J C Kleinjans. (1995-03-01) Induction of oxidative DNA damages and enhancement of cell proliferation in human lymphocytes in vitro by butylated hydroxyanisole.. Carcinogenesis, 16 ((3)): (507-512). [PMID:7697806]
20. J H Chung,Y N Cha,R J Rubin. (1994-01-01) Role of quinone reductase in in vivo ethanol metabolism and toxicity.. Toxicology and applied pharmacology, 124 ((1)): (123-130). [PMID:8291053]
21. Yu Miao,Yanling Wu,Yingjin Jin,Mengze Lei,Jixing Nan,Xue Wu. (2020-01-15) Benzoquinone derivatives with antioxidant activity inhibit activated hepatic stellate cells and attenuate liver fibrosis in TAA-induced mice.. Chemico-biological interactions, 317 (108945-108945). [PMID:31935363]
22. Ningxiang Yu, Zeyi Wu, Yijue Wang, Abel Wend-Soo Zongo, Xiaohua Nie, Yuanchao Lu, Qin Ye, Xianghe Meng. (2024) Formation of adducts during digestion triggered dietary protein for alleviating cytotoxicity of 2-tert-butyl-1,4-benzoquinone. FOOD AND CHEMICAL TOXICOLOGY, 183 (25): (114200). [PMID:38029872] [10.1016/j.fct.2023.114200]

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2-tert-Butyl-1,4-benzoquinone - ≥98.0%(GC), high purity , CAS No.3602-55-9