| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| D275807-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $385.90 |
Selective PPARγ agonist
| Synonyms | 15-deoxy- delta 12,14-prostaglandin J2 | 15-Deoxy-DELTA(12,14)-PGJ2 | (5Z,12E,14E)-11-oxo-prosta-5,9,12,14-tetraen-1-oate | HMS1361E03 | 15-Deoxy-delta12,14-prostaglandin | BDBM50270612 | HMS1791E03 | (Z)-7-[(1S,5E)-5-[(E)-oct-2-enylidene]-4-oxo-1-cyclope |
|---|---|
| Specifications & Purity | Moligand™, ≥97% |
| Biochemical and Physiological Mechanisms | Selective agonist to PPARγ. Inhibits the proliferation of cancer cell lines (IC 50 = 22 μM). Differentiates C3H10T1/2 fibroblasts into adipocytes. Active in vitro . |
| Storage Temp | Store at -20°C,Desiccated |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Action Type | AGONIST |
| Mechanism of action | Agonist of Peroxisome proliferator-activated receptor-γ |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| IUPAC Name | (Z)-7-[(1S,5E)-5-[(E)-oct-2-enylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid |
|---|---|
| INCHI | InChI=1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6+,18-13+/t17-/m0/s1 |
| InChi Key | VHRUMKCAEVRUBK-GODQJPCRSA-N |
| Canonical SMILES | CCCCCC=CC=C1C(C=CC1=O)CC=CCCCC(=O)O |
| Isomeric SMILES | CCCCC/C=C/C=C/1\[C@H](C=CC1=O)C/C=C\CCCC(=O)O |
| PubChem CID | 5311211 |
| Molecular Weight | 316.5 |
Starting at $173.90
| 1. Koma H et al.. (2019) 15-deoxy-?12, 14-prostaglandin J2 enhances anticancer activities independently of VHL status in renal cell carcinomas.. Biochem Biophys Rep, 18 (100608). [PMID:30815591] |
