1,2-distearoyl-sn-glycero-3-phosphocholine - >99%, high purity , CAS No.816-94-4

  • ≥99%
Item Number
D130429
Grouped product items
SKUSizeAvailabilityPrice Qty
D130429-25mg
25mg
3
$16.90
D130429-100mg
100mg
3
$53.90
D130429-500mg
500mg
3
$173.90
D130429-1g
1g
5
$313.90
D130429-5g
5g
2
$1,409.90

Phosphorylcholine with stearic acid

Basic Description

SynonymsDSPC | PC(18:0/18:0) | [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate | (R)-(7-Lauroyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacosyl)trimethylammonium 4-oxide | HY-W040193 | BP-25623 | 1,2-Distearoyl-sn-glycero-3-phosphocholi
Specifications & Purity≥99%
Biochemical and Physiological MechanismsPhosphorylcholine with stearic acid. For use in lipid bilayer studies and biological systems.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Non-pyrogenic, well-defined liposomes, loaded with a molecule of choice, are formed by a single hydration step. 1,2-Distearoyl-sn-glycero-3-phosphocholine is a non-pyrogenic phospholipid that has been shown to form well-defined liposomes that are capable of being loaded with a molecule of choice. This loading and vessicle formation is reportedly accomplished simply by a single hydration step. Research has shown that this encapsulation technique has been shown to increase the uptake for 125I-labelled polyvinylpyrrolidone by four times in an intestinal sac preparation from adult rats. More recently, compounds such as 5-fluorouracil ,cyclosporin A and celecoxib have been used in this lipid encapsulation technique.
Used to produce non-pyrogenic liposome capable of caging molecules

AI Insight

Names and Identifiers

Pubchem Sid488186814
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488186814
IUPAC Name [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
INCHI InChI=1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1
InChi Key NRJAVPSFFCBXDT-HUESYALOSA-N
Canonical SMILES CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC
Isomeric SMILES CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC
WGK Germany 3
PubChem CID 94190
Molecular Weight 790.14
Beilstein 3923978

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

29 results found

Lot NumberCertificate TypeDateItem
F2327320Certificate of AnalysisApr 02, 2025 D130429
F2327315Certificate of AnalysisApr 02, 2025 D130429
F2327313Certificate of AnalysisApr 02, 2025 D130429
F2327311Certificate of AnalysisApr 02, 2025 D130429
F2327306Certificate of AnalysisApr 02, 2025 D130429
F2327305Certificate of AnalysisApr 02, 2025 D130429
F2327301Certificate of AnalysisApr 02, 2025 D130429
F2327299Certificate of AnalysisApr 02, 2025 D130429
L2424611Certificate of AnalysisDec 17, 2024 D130429
L2424607Certificate of AnalysisDec 17, 2024 D130429
A2507139Certificate of AnalysisDec 17, 2024 D130429
J2415790Certificate of AnalysisSep 27, 2024 D130429
G2220710Certificate of AnalysisMay 15, 2024 D130429
G2220708Certificate of AnalysisMay 15, 2024 D130429
G2220523Certificate of AnalysisMay 15, 2024 D130429
G2220522Certificate of AnalysisMay 15, 2024 D130429
A2415293Certificate of AnalysisJan 03, 2024 D130429
A2415278Certificate of AnalysisJan 03, 2024 D130429
A2415279Certificate of AnalysisJan 03, 2024 D130429
J2409103Certificate of AnalysisJan 03, 2024 D130429
A2415294Certificate of AnalysisJan 03, 2024 D130429
B2225377Certificate of AnalysisDec 11, 2023 D130429
F2327308Certificate of AnalysisJun 13, 2023 D130429
L2312027Certificate of AnalysisJun 13, 2023 D130429
B2328192Certificate of AnalysisJun 22, 2022 D130429
B2225374Certificate of AnalysisDec 30, 2021 D130429
B2225375Certificate of AnalysisDec 30, 2021 D130429
B2225383Certificate of AnalysisDec 30, 2021 D130429
B2225601Certificate of AnalysisDec 30, 2021 D130429

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Safety and Hazards(GHS)

Signal Warning
Hazard Statements

H319:Causes serious eye irritation

H317:May cause an allergic skin reaction

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

WGK Germany 3

Related Documents

Reviews

Customer Reviews

Citations of This Product

1. Yuqian Fu, Tingjie Bai, Panpan Xue, Qi Chen, Weili Deng, Shuangqian Yan, Xuemei Zeng.  (2023)  Glycolysis inhibition for synergistic phototherapy of triple-negative breast cancer.  Journal of Materials Chemistry B,  11  (44): (10717-10727).  [PMID:37921004] [10.1039/D3TB02059B]
2. Weilun Pan, Bodeng Wu, Chengtao Nie, Tingting Luo, Zhenli Song, Jie Lv, Yong Tan, Chunchen Liu, Mingzhen Zhong, Tong Liao, Zhenxun Wang, Guanghui Yi, Limin Zhang, Xiaoliu Liu, Bo Li, Jinxiang Chen, Lei Zheng.  (2023)  NIR-II Responsive Nanohybrids Incorporating Thermosensitive Hydrogel as Sprayable Dressing for Multidrug-Resistant-Bacteria Infected Wound Management.  ACS Nano,  17  (12): (11253–11267).  [PMID:37314783] [10.1021/acsnano.2c10742]
3. Jing Su, Weijia Lu, Yexuan Guo, Zhuoyi Liu, Xu Wang, Hong Yan, Rui Xue Zhang.  (2023)  Depot unilamellar liposomes to sustain transscleral drug Co-delivery for ophthalmic infection therapy.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,  86  (104629).  [PMID:] [10.1016/j.jddst.2023.104629]
4. Xuetong Qu, Bin He, Zekuan Li, Xinrong Jiang, Xingyue Liu, Xisheng Chen, Xiaoming Chen, Xiao Liang, Zhijun Jiang, Jianmin Wu.  (2023)  Accurate Discrimination of Benign Biliary Diseases and Cholangiocarcinoma with Serum Multiomics Revealed by High-Throughput Nanoassisted Laser Desorption Ionization Mass Spectrometry.  JOURNAL OF PROTEOME RESEARCH,  22  (6): (1855–1867).  [PMID:37218629] [10.1021/acs.jproteome.2c00846]
5. Mengmeng Zhang, Xiaoyang Wang, Yajun Zhang, Yiqiang Fan.  (2023)  Integrated sample processing and counting microfluidic device for microplastics analysis.  ANALYTICA CHIMICA ACTA,  1261  (341237).  [PMID:37147054] [10.1016/j.aca.2023.341237]
6. Run Han, Zhuyifan Ye, Yunsen Zhang, Yaxin Cheng, Ying Zheng, Defang Ouyang.  (2023)  Predicting liposome formulations by the integrated machine learning and molecular modeling approaches.  Asian Journal of Pharmaceutical Sciences,  18  (100811).  [PMID:37274923] [10.1016/j.ajps.2023.100811]
7. Tsogzolmaa Ganbold, Qingming Bao, Hai Xiao, Dolgorsuren Zurgaanjin, Caifeng Liu, Shuqin Han, Agula Hasi, Huricha Baigude.  (2022)  Peptidomimetic Lipid-Nanoparticle-Mediated Knockdown of TLR4 in CNS Protects against Cerebral Ischemia/Reperfusion Injury in Mice.  Nanomaterials,  12  (12): (2072).  [PMID:35745411] [10.3390/nano12122072]
8. Xuetong Qu, Tao Wang, Xingyue Liu, Xinrong Jiang, Xiao Liang, Jianmin Wu.  (2022)  Dual-Mechanism-Driven Strategy for High-Coverage Detection of Serum Lipids on a Novel SALDI-MS Target.  ANALYTICAL CHEMISTRY,  94  (24): (8570–8579).  [PMID:35670384] [10.1021/acs.analchem.1c04929]
9. Hui Jiang, Shi-Jun Yin, Xu Wang, Min Lu, Hao Zhang, Feng-Qing Yang.  (2022)  Preparation of covalently bonded liposome capillary column and its application in evaluation of drug membrane permeability.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  209  (114513).  [PMID:34883420] [10.1016/j.jpba.2021.114513]
10. Zhu Yutao, Hu Xiaoqian, Wang Ping, Gao Linying, Pei Yakun, Ge Zhaoyue, Ge Xiaoyang, Li Fuguang, Hou Yuxia.  (2021)  GhPLP2 Positively Regulates Cotton Resistance to Verticillium Wilt by Modulating Fatty Acid Accumulation and Jasmonic Acid Signaling Pathway.  Frontiers in Plant Science,  12    [PMID:34795685] [10.3389/fpls.2021.749630]
11. Jiahao Li, Xuping Wu, Yue Li, Xin Wang, Huachuan Huang, Dan Jian, Yanke Shan, Yue Zhang, Chengcheng Wu, Guolei Tan, Shouyu Wang, Fei Liu.  (2021)  Amplification-free smartphone-based attomolar HBV detection.  BIOSENSORS & BIOELECTRONICS,  194  (113622).  [PMID:34543826] [10.1016/j.bios.2021.113622]
12. Hui Jiang, Hao Zhang, Shi-Jun Yin, Min Lu, Xu Wang, Feng-Qing Yang.  (2021)  Determination of lipid–water partition coefficient of neutral and ionic drugs by liposome electrokinetic chromatography.  ELECTROPHORESIS,  42  (14-15): (1436-1449).  [PMID:33908064] [10.1002/elps.202000382]
13. Fangman Chen, Fan Zhang, Dan Shao, Weibin Zhang, Liqin Zheng, Wei Wang, Wendi Yang, Zheng Wang, Jianxin Chen, Wen-fei Dong, Fangnan Xiao, Yunkun Wu.  (2020)  Bioreducible and traceable Ru(III) prodrug-loaded mesoporous silica nanoparticles for sequentially targeted nonsmall cell lung cancer chemotherapy.  Applied Materials Today,  19  (100558).  [PMID:] [10.1016/j.apmt.2020.100558]

References

1. Yuqian Fu, Tingjie Bai, Panpan Xue, Qi Chen, Weili Deng, Shuangqian Yan, Xuemei Zeng.  (2023)  Glycolysis inhibition for synergistic phototherapy of triple-negative breast cancer.  Journal of Materials Chemistry B,  11  (44): (10717-10727).  [PMID:37921004] [10.1039/D3TB02059B]
2. Weilun Pan, Bodeng Wu, Chengtao Nie, Tingting Luo, Zhenli Song, Jie Lv, Yong Tan, Chunchen Liu, Mingzhen Zhong, Tong Liao, Zhenxun Wang, Guanghui Yi, Limin Zhang, Xiaoliu Liu, Bo Li, Jinxiang Chen, Lei Zheng.  (2023)  NIR-II Responsive Nanohybrids Incorporating Thermosensitive Hydrogel as Sprayable Dressing for Multidrug-Resistant-Bacteria Infected Wound Management.  ACS Nano,  17  (12): (11253–11267).  [PMID:37314783] [10.1021/acsnano.2c10742]
3. Jing Su, Weijia Lu, Yexuan Guo, Zhuoyi Liu, Xu Wang, Hong Yan, Rui Xue Zhang.  (2023)  Depot unilamellar liposomes to sustain transscleral drug Co-delivery for ophthalmic infection therapy.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,  86  (104629).  [PMID:] [10.1016/j.jddst.2023.104629]
4. Xuetong Qu, Bin He, Zekuan Li, Xinrong Jiang, Xingyue Liu, Xisheng Chen, Xiaoming Chen, Xiao Liang, Zhijun Jiang, Jianmin Wu.  (2023)  Accurate Discrimination of Benign Biliary Diseases and Cholangiocarcinoma with Serum Multiomics Revealed by High-Throughput Nanoassisted Laser Desorption Ionization Mass Spectrometry.  JOURNAL OF PROTEOME RESEARCH,  22  (6): (1855–1867).  [PMID:37218629] [10.1021/acs.jproteome.2c00846]
5. Mengmeng Zhang, Xiaoyang Wang, Yajun Zhang, Yiqiang Fan.  (2023)  Integrated sample processing and counting microfluidic device for microplastics analysis.  ANALYTICA CHIMICA ACTA,  1261  (341237).  [PMID:37147054] [10.1016/j.aca.2023.341237]
6. Run Han, Zhuyifan Ye, Yunsen Zhang, Yaxin Cheng, Ying Zheng, Defang Ouyang.  (2023)  Predicting liposome formulations by the integrated machine learning and molecular modeling approaches.  Asian Journal of Pharmaceutical Sciences,  18  (100811).  [PMID:37274923] [10.1016/j.ajps.2023.100811]
7. Tsogzolmaa Ganbold, Qingming Bao, Hai Xiao, Dolgorsuren Zurgaanjin, Caifeng Liu, Shuqin Han, Agula Hasi, Huricha Baigude.  (2022)  Peptidomimetic Lipid-Nanoparticle-Mediated Knockdown of TLR4 in CNS Protects against Cerebral Ischemia/Reperfusion Injury in Mice.  Nanomaterials,  12  (12): (2072).  [PMID:35745411] [10.3390/nano12122072]
8. Xuetong Qu, Tao Wang, Xingyue Liu, Xinrong Jiang, Xiao Liang, Jianmin Wu.  (2022)  Dual-Mechanism-Driven Strategy for High-Coverage Detection of Serum Lipids on a Novel SALDI-MS Target.  ANALYTICAL CHEMISTRY,  94  (24): (8570–8579).  [PMID:35670384] [10.1021/acs.analchem.1c04929]
9. Hui Jiang, Shi-Jun Yin, Xu Wang, Min Lu, Hao Zhang, Feng-Qing Yang.  (2022)  Preparation of covalently bonded liposome capillary column and its application in evaluation of drug membrane permeability.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  209  (114513).  [PMID:34883420] [10.1016/j.jpba.2021.114513]
10. Zhu Yutao, Hu Xiaoqian, Wang Ping, Gao Linying, Pei Yakun, Ge Zhaoyue, Ge Xiaoyang, Li Fuguang, Hou Yuxia.  (2021)  GhPLP2 Positively Regulates Cotton Resistance to Verticillium Wilt by Modulating Fatty Acid Accumulation and Jasmonic Acid Signaling Pathway.  Frontiers in Plant Science,  12    [PMID:34795685] [10.3389/fpls.2021.749630]
11. Jiahao Li, Xuping Wu, Yue Li, Xin Wang, Huachuan Huang, Dan Jian, Yanke Shan, Yue Zhang, Chengcheng Wu, Guolei Tan, Shouyu Wang, Fei Liu.  (2021)  Amplification-free smartphone-based attomolar HBV detection.  BIOSENSORS & BIOELECTRONICS,  194  (113622).  [PMID:34543826] [10.1016/j.bios.2021.113622]
12. Hui Jiang, Hao Zhang, Shi-Jun Yin, Min Lu, Xu Wang, Feng-Qing Yang.  (2021)  Determination of lipid–water partition coefficient of neutral and ionic drugs by liposome electrokinetic chromatography.  ELECTROPHORESIS,  42  (14-15): (1436-1449).  [PMID:33908064] [10.1002/elps.202000382]
13. Fangman Chen, Fan Zhang, Dan Shao, Weibin Zhang, Liqin Zheng, Wei Wang, Wendi Yang, Zheng Wang, Jianxin Chen, Wen-fei Dong, Fangnan Xiao, Yunkun Wu.  (2020)  Bioreducible and traceable Ru(III) prodrug-loaded mesoporous silica nanoparticles for sequentially targeted nonsmall cell lung cancer chemotherapy.  Applied Materials Today,  19  (100558).  [PMID:] [10.1016/j.apmt.2020.100558]

Solution Calculators